Searchable abstracts of presentations at key conferences in endocrinology

ea0032oc6.4 | Diabetes & Obesity | ECE2013

Reduction of fat mass with the mTOR inhibitor, sirolimus, in humans: from transplantation to lipodystrophies

Parent Emilie , Pattou Francois , Ernst Olivier , Lion Georges , Wolowczuk Isabelle , Dharancy Olivier , Noel Christian , Kerr-Conte Julie , Vantyghem Marie-Christine

Objectives: Sirolimus inhibits adipocyte differentiation (Yeh PNAS 1995). This study compares weight and fat markers in two groups of patients treated or not with sirolimus, before and after transplantation.Patients and method: Nineteen islet-alone transplanted patients treated with sirolimus and 7 islet-alone or liver-transplanted patients NOT treated with sirolimus were compared 1 year after transplantation in terms of weight, fat mass (equation of bod...